commentr/StutterNovember 22, 2024

Content

Emboldened by simply the sheer size of research and number of observed differences between PWS and the fluent? I'd rather bet overwhelmed and barely understanding of the pursuit you propose. Does your essay lay out and map together the abnormalities in the orientation and integrity of white matter fibers in the brain, particularly the findings of fractional anisotropy indicating lower integrity of longitudinal fibers in the arcuate fasciculus and the transverse fibers potentially disrupting connectivity in the corpus callosum? And the altered corpus callosum structure where it has increased mass but decreased connectivity? Or DMN altered function? And disrupted connection between cerebellum and left brodmann area 46, namely orbitofrontal cortex? And the anomalous overactivation and dopamine production in the basal ganglia? And the lack thereof in the cortex? And spike-timing dependent plasticity, namely role of LTP of synaptic connections? And special hemisphere functionalization and its implications in stuttering? And the amplification of locomotor activity due to disinhibition of pathway from the subpallidal area to the VTA? I could keep going from memory alone because I've been studying for around 5 years now. And go further if I sat down to look at notes. And I'm a novice. Infant. Go to neuroscience servers on discord and propose this idea to professors and postdocs there. Do you know what they will tell you? "I'm not qualified to answer because it's not my area of expertise. If you want to ask anything about molecular biology or this or that, do not hesitate." They are seasoned professionals and yet more cautious than you are with your aspirations. I'm a layman with years of study. I'm genuinely interested. What's your deal? What did you study or see that emboldened you to believe you could compress the literature in a neat little pill? I'm not attacking you bro. I was the same. But OP and others don't owe you or me being assholes absolutely unprompted.

Themes

Causes & VariabilityCommunity & SupportEmotional Experience

Subthemes

Neurological & BrainResearch & ResourcesHelplessness & Agency