I love the enthusiasm that you are bringing here, it's great. It sounds like what you're trying to understand is what is the role of dopamine in stuttering? And that is a great question to ask. To add to what you are saying. What you are talking about matches onto the increased activation we see in the default mode network, a network primarily involved with self referential thinking. However, this is more of a symptom of stuttering rather than an underlying cause. My main question here is what citations do you have to back up what you are saying? A few other concerns: 1. You said, "Rewarding: it dampens our sensitivity so that the rises in synaptic dopamine are no longer so rewarding" That's not possible. A rewarding stimulus elicits a rise in dopamine, rather than dopamine eliciting a pleasurable feeling. 2. "Stuttering occurs as a direct result of phasic reductions in synaptic dopamine. brought on by the perception (or anticipation) of communication failure." * The evidence for dopamine dysregulation is mainly in elevated dopamine levels, rather than reductions. I can provide citations if you like. * Your statement states that the reductions are brought on AFTER the stuttering moment. What we're concerned about are the events preceding and during a stuttering moment, not afterwards. And quite frankly, there have been no real time dopamine studies done on PWS while speaking. Again, I love the enthusiasm and passion. I am passionate about this too. However, we can only truly make progress if we stick to the research.