Alright. "Shitty parenting" is how we access stimulants. Nictotine and sugar may be relatively weak, but when you consider consumption frequency and how it's re-consumed every few seconds/minutes -- not so inconsequential anymore. Gamer w/ Doritos and Mountain Dew on the desk every hour. Teen in bed clutching a vape while napping. With all due respect, your degree on genetics gives you a bias on the topic -- "everything is genetics". That's a victim mentality approach and not helpful for people looking for solutions after their birth. Everything I said in my first reply is from Dr. Robert Lustig, condensed and paraphrased. Fructose kills neurons -- plain and simple. Saying "blaming Dopamine is trendy" really sounds like shilling for processed food corps. We're strictly discussing clinical biochemical mechanics in this context. \> Parkinson's Disease (PD) is the second most common neurodegenerative disease and is associated with significant morbidity ([**1**](https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full#B1)). It is characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta, and a deficiency of dopamine in the striatum and other basal ganglia structures. A growing body of evidence suggests that nutrition may play an important role in PD ([**2**](https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full#B2)). \[source\]([https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full](https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full)) \> I don’t see how we gentle people have any aberration in brain dopamine (coffee, nicotine and alcohol are weak stimulants). And you obviously don’t have access to any stimulant during the period of gaining self-awareness in childhood ... Soda has caffeine and fructose (aka alcohol). Vapes have nicotine. \> A growing body of evidence suggests that nutrition may play an important role in PD ... Interestingly, PD patients are also purported to display a preference for sweet foods, such as cakes ([**11**](https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full#B11)), chocolate ([**12**](https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full#B12)), ice cream ([**13**](https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full#B13)), milk puddings and custards ([**14**](https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full#B14)), consistent with an increased consumption of carbohydrates ([**7**](https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full#B7), [**15**](https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full#B15), [**16**](https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full#B16)). It's very clear how Dopamine products damage neurons. I've linked a handful of references. "Source: degree" is a bit silly in a subreddit where people are trying to figure out by trial/error how to speak normally and get their normal lives back. Sentiments like "you can't change genetics" or providing "dead end" throwaway comments is not helping to provide next steps for researchers.