postr/StutterSeptember 18, 2025

What’s the current status of the Ecopipam trials?

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What’s the current status of the Ecopipam trials? Does anyone know what the current status is of the Ecopipam trials for treating stuttering? For those of you who don’t know, Ecopipam is used for treating Tourettes Syndrome, and has been found to significantly improve fluency for stutterers too. Ecopipam essentially works by blocking D1 dopamine receptors in the brain, especially in motor and reward circuits. For stuttering, this means it may reduce the overactive, poorly timed dopamine signalling in the basal ganglia that disrupts speech flow — potentially leading to smoother, more fluent speech without the heavy side effects of older dopamine-blocking drugs.

Themes

Anticipation & AvoidanceMeds & Substances

Subthemes

Overthinking & MonitoringHelpful Med Outcomes

Codes (1)

dopamine_modulators_vmat2_inhibitors