Yeah it really helped a lot. My wife didn’t notice a difference until I quit taking it, and went back to my old speech. Only real side effect I had was it made me SUPER tired. I had to take it at night. The Trial I am starting now is for NOE-105. I have the same doctor as before and he said out of the 3 people that were in the first trial out of his office I was the only one to show any type of improvement. The ecopipam I guess works with the D1 receptors, This NOE-105 is supposed to work with the D2 receptors.