Based on the fact that my initial regimen was a lower dose with lower 'bioavailability' of the supplements, I would guess yes that the dosage does matter. I think that if I lowered the dosage and/or switched to an inferior version of these supplements, the regimen would be less effective. It all sounds a bit mad scientist but from my previous post above I mentioned something about the blood-brain barrier. Speaking for myseIf think that what's happening is that I need enough concentration of the supplements in my blood to be able to pass the blood brain barrier and basically get into my brain :O So far it's been 1 week and still going strong :)